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p53-pS15 combined with FOXO4 in the nucleus of senescent cells inhibits p53 into the cytoplasm to mediate apoptosis and halt the cell cycle 9,11
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The ability to form these alternative secondary metabolites may be of considerable physiological importance in species, like the trout, that are unable to produce AFB 1 -GSH conjugates
Epigenetic regulation of ec-sod expression in aging lung fibroblasts: role of histone acetylation
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