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15 The gene for glutathione peroxidase-4 is expressed in most tissues, including the brain (Gene Expression Atlas, available at Although the GPX4 gene is highly polymorphic, a limited number of studies 16, 17, 18, 19 have been done to investigate genetic variations within the GPX4 gene that could potentially alter the function of the enzyme
J.GolovskyD.BrennerP
We also define priorities for optimizing CNS delivery, mitigating toxicities (e.g., cytokine-release syndrome(CRS)), engineering dual-antigen constructs to counter heterogeneity and antigen escape, and designing rational combination regimens
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