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Nausea is by far the most commonly reported symptom and tends to appear early, especially during dose increases. Vomiting, diarrhea, and constipation can also occur, though their frequency depends on the specific medication and dose

When the functional group attacking the amide is a thiol, hydroxyl or amine, the resulting molecule may be called a cyclol or, more specifically, a thiacyclol, an oxacyclol or an azacyclol, respectively

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