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The mechanism is fascinating: Unlike GLP-1 agonists that work on gut hormones, tesofensine directly modulates brain neurotransmitters controlling appetite and energy expenditure
It is one of the most studied peptides in skincare and longevity research, widely discussed by anti-aging researchers and biohackers for its role in collagen and tissue-remodeling pathways
Diabetes 16, 12501262
In the REDEFINE 2 trial in patients with type 2 diabetes, it achieved 13.7% weight loss and brought 73.5% of patients to HbAc 6.5% ( [141] )
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