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the most frequently reported AE were gastrointestinal related, with nausea as the most common AE which 24.8% of participants in semaglutide group experienced, following by diarrhea (13.7%), and vomiting (13.0%) in comparison with the placebo group (9.7%, 8.7%, 3.2%, respectively)
Additionally, scientists discovered that up to 72.3% of participants in the treatment group lower their weight by at least 5%
For example, according to a meta-analysis of randomised controlled trials, therapies with GLP-1 receptor agonists significantly reduced cardiovascular events and improved cardiometabolic parameters
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