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This makes it a good choice for eligible participants
The SUSTAIN-6 cardiovascular outcomes trial established that semaglutide also reduces the risk of major adverse cardiovascular events (MACE) by 26% relative to placebo in high-risk patients a finding that fundamentally changed the treatment landscape for metabolic disease
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Future studies using radiolabeled TZP and transporter inhibitors (e.g., P-glycoprotein inhibitors) are needed to confirm this mechanism
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