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2021 Sep 15;13(1):99
Because tirzepatide typically produces greater total body weight loss than semaglutide, patients on tirzepatide may experience more pronounced facial volume changes than those on semaglutide at comparable timeframes
Large-scale RCTs are required to rigorously validate these early findings, and encouragingly, we are already starting to see several studies exploring these areas
Interestingly, a study that did implement this titration approach found during the maintenance phase, rats treated with semaglutide showed a unexpected marked increase in the intake of lower concentrations of sucrose compared to vehicle treated controls, despite continuing to consume chow at only 90% the level of vehicle-treated animals ( In line with clinical data, GLP-1R agonism may also directly influence food preference through modulation of taste receptor expression
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