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While millions of patients adapt to these medications, a collective truth has emerged: gastrointestinal side effects are highly prevalent

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In vitro drug release studies in simulated intestinal fluid (SIF) and gastric fluids (SGF) revealed that over 80% of the two drugs were released within 5 h in SGF, with a sustained release observed up to 24 h in SIF

When weight reduction exceeds approximately 1.5 kg per week during early therapy, clinicians should remain alert