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In SUSTAIN-6, retinopathy complications were higher (3.0% vs 1.8% with placebo), likely tied to fast blood-sugar improvement in people who already had retinopathy
GLP-1 medications can affect thyroid function, and persistent fatigue may indicate thyroid hormone changes requiring medication adjustment rather than electrolyte-only intervention
Elevated glucose concentrations activate the RAAS, constricting efferent arterioles and thereby increasing intraglomerular pressure [25]
Confirm peptide concentration (typically 1-3% for efficacy) and verify third-party certificates of analysis for ingredient purity
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