![glp 1 degradation GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] PDB-101: Molecule of the Month:](https://www.preprints.org/frontend/picture/ms_xml/manuscript/c9c3cd16d3db64faa79714c50b5bb790/preprints-181961-g001.png)
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Biosynthesis runs through two ATP-dependent steps, glutamate-cysteine ligase (EC 6.3.2.2) followed by glutathione synthetase
![glp 1 degradation GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] PDB-101: Molecule of the Month:](https://cdn.rcsb.org/pdb101/motm/311/peptide_agonists.png)
These numbers are terrible
![glp 1 degradation GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] PDB-101: Molecule of the Month:](https://www.researchgate.net/profile/Brian-Green-14/publication/8037828/figure/fig4/AS:668736923136002@1536450715123/Degradation-profiles-of-A-and-B-GLP-1-C-N-acetyl-GLP-1-and-D-N-pyroglutamyl-GLP-1.png)
Less chewing and fluid triggers dryness
![glp 1 degradation GLP-1 Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] PDB-101: Molecule of the Month:](https://journals.physiology.org/cms/10.1152/physrev.00034.2006/asset/images/medium/z9j0040724440003.jpeg)
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