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IGF-1 promotes cell proliferation and tissue growth, which raises theoretical concerns about tumor growth or cancer risk, especially in individuals with pre-existing tumors or a family history of cancer

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These differences are not unexpected given that SUSTAIN 6 and PIONEER 6 included subjects at high risk of CVD, and PIONEER 5 included subjects with renal impairment

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doi: 10.1007/s00253-010-2631-2 155 WangY.CaoS.SuiX.WangJ.GengY.GaoF.et al

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