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Additionally, metabolic adaptations that occur during weight lossincluding reduced energy expenditure and hormonal changes that promote weight regainare no longer counteracted by the medication's effects
the specific escalation steps and intervals were defined by the trial protocol
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doi: 10.1053/j.gastro.2014.11.020 63 MirasAPevidaBEAldhwayanMKamockaAMcGloneERAl-NajimWet al
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