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In contrast, in the Cagri-AMY 1 R-Gs structure, L119 RAMP1 is likely to clash with a rearranged imidazole side chain of H296 ECL2 that is observed when Cagri is bound to CTR and likely accounts for the different orientation of the linker in the Cagri bound AMY 1 R (Fig

The peptides work on different molecular targets while both contributing to angiogenesis through separate pathways