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For those who can tolerate semaglutide's side effects, the degree of weight loss - potentially up to 20% of baseline weight - along with improvements in obesity-related health indicators may justify persistence through the initial adverse effects
12 In contrast, no benefit of GLP-1 RAs was observed in terms of all-cause death, HF hospitalisation or cardiovascular death
GLP-1s for weight management are now accounting for an average of 10.5% of total annual claims for employers in 2025, up from 8.9% in 2024 and 6.9% in 2023
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