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Pharmacokinetics of tirzepatide demonstrated dose proportionality over the wide dose range, with C max of 180 nM in individuals treated with one dose of 8 mg and a C max of 260 nM with 15 mg/week dose in the clinical study, exceeding the EC50 values for GIPR and GLP-1R activations by approximately 10,000-fold and 250-fold, respectively (63)
Durrant, J
Consider establishing an objective monitoring plan around GLP-1 initiation, including baseline and follow-up inflammatory markers (C-reactive protein, fecal calprotectin) and maintaining a symptom diary to help differentiate medication side effects from disease activity
GLP-1 (glucagon-like peptide-1) is a hormone that helps regulate appetite and food intake
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