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For many decades, advancements in inhaled therapies typically delivered using nebulizers or dry powder inhalers (Box 1) have focused on modulating mucus to support both lung defence and drug delivery (Fig

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Indeed, because more than 100 proteins have been reported as TG2 substrates and because TG2 has broad substrate specificity, the GST tag could be crosslinked with a number of cellular proteins 21

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