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Wegovy (semaglutide) is a GLP-1 receptor agonist used for weight management in adults with obesity or overweight with comorbidities

Discussion Our findings demonstrate that GLP-1 receptor agonist-based therapeutics significantly disrupt the interoceptive stimulus effects of alcohol, highlighting a potential therapeutic mechanism through which these medications may reduce alcohol consumption and motivation

Tatemoto K, Carlquist M, Mutt V

Thus, truncation of the C-terminal L585 residue of the GLP-1 fusion containing WT albumin reduces its cellular recycling in vitro and plasma half-life in vivo, which may be compensated for by QMP engineering of albumin, irrespective of the presence of L585