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Wegovy uses the same active ingredient as Ozempic that has been approved for weight loss in the UK
In the Lira Pump study, they decreased basal insulin by 10%, but increased bolus by 15% ( Our current practice is to consider a ~20% bolus insulin decrease and a ~10% basal insulin decrease before GLP-1RA initiation, although prior A1c, risk of hypoglycemia, potential risk of ketosis due to reduced insulin doses, as well as other patient-specific factors should guide the final insulin dose changes
(2010) Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor
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