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Based on differences in the carbon skeleton, phenolic acids can be mainly divided into two categories: hydroxycinnamic acid (e.g., cinnamic acid, ferulic acid, caffeic acid, and chlorogenic acid) and hydroxybenzoic acid (e.g., gallic acid, ellagic acid, syringic acid, and Danshensu) [157]
Anti-inflammatory activity is a third shared mechanism, with BPC-157 down-regulating NF-B and TB-500 suppressing TNF- and IL-1 in independent preclinical models
About 1020% of patients are non-responders or modest responders
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