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It's not dangerous, but it can: Add 13kg of scale weight (masking actual fat loss) Cause visible puffiness in legs or hands Be uncomfortable if severe What to do if you notice edema: Reduce KLOW dose by 50% and reassess after 2 weeks If on a daily frequency, drop to 3x/week If it persists, switch to pinning BPC-157 and GHK-Cu separately, leaving TB-500 out until the edema resolves Stay well-hydrated (counterintuitively, more water can help flush the retained fluid) Most people find edema resolves once the body adapts in weeks 24, or by reducing frequency

Christen U, von Herrath MG (2011) Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference

In clinical trials (e.g., SURMOUNT-1), tirzepatide led to significant weight loss, an average weight loss of 15%20% of body weight over 72 weeks, when combined with diet and exercise

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