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Cuadrado A (2022) Brain-protective mechanisms of transcription factor NRF2: toward a common strategy for neurodegenerative diseases
Potential side effects & safety considerations Due to limited available data, assessing 5-Amino-1MQ side effects is challenging
Wang as previously described and provided by C
Along with a significant pool of preclinical data on the effect of GLP-1RAs (including exendin-4) on PD models in experimental animals, showing a decrease in the loss of dopaminergic neurons and accumulation of -synuclein in the brain, a decrease in mitochondrial dysfunction and expression of pro-inflammatory mediators such as tumor necrosis factor (TNF)- and interleukin IL-1 [61], promising data from clinical studies on the use of GLP-1RAs in PD have been obtained [62]
