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Mechanism of action: Activates both GLP-1 receptors AND GIP (glucose-dependent insulinotropic polypeptide) receptors simultaneously GIP receptors in fat tissue directly regulate lipid metabolism and fat cell energy storage Dual activation creates a synergistic effect on appetite suppression and energy expenditure Produces stronger improvement in insulin sensitivity compared to GLP-1-only medications FDA-approved brand names: Zepbound approved for chronic weight management Mounjaro approved for type 2 diabetes Why does the dual mechanism matter

Hydration and electrolytes round it out

At the same time, GLP-1s are taking on a larger role in the broader metabolic treatment landscape

CagriSema REDEFINE 2: Cagrilintide-Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes