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Similarly, CPUY192018, a potent small-molecule inhibitor of the Keap1-Nrf2 PPI, demonstrated cytoprotective effects in NCM460 colonic cells and a DSS-induced UC model by activating Nrf2 signaling (262)
When repeated administration is expected to be relevant for the future therapeutic use of the compound, the study may subsequently progress to a Multiple Ascending Dose (MAD) phase
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