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While incretin-based therapies have been commercially available since 2005, most clinical trials only report short term outcomes
Moreover, mitochondrial dysfunction and ER oxidative stress have been identified as key factors in the induction of myocardial apoptosis in diabetic myocardial models
GGCT channels Gln flux for GSH synthesis and Glc anaplerosis into the TCA cycle ROS act as signaling molecules that regulate mitochondrial function, with mitochondrial morphology intrinsically linked to core processes, including the TCA cycle and oxidative phosphorylation
Common side effects may include gastrointestinal symptoms such as nausea, vomiting, or diarrhea, which often diminish over time
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