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In the 52-week SURPASS-4 trial TZP was tested versus insulin glargine in diabetic adults and a high CV risk below not sufficient GC at baseline and in therapy with one to three oral glucose-lowering drugs (metformin, sulfonylurea, SGLT2-i)
A randomized controlled trial showed significant reductions in weight, BMI, waist circumference, and fasting insulin levels with metformin treatment
Again, because compounded semaglutide has not been tested in clinical trials, we dont know if compounded semaglutide is safe or effective, Dr
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