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Food & Drug Administration (FDA) for general medical use
Referral for evaluation for metabolic and bariatric surgery may be appropriate for patients with BMI 35 kg/m with obesity-related complications or BMI 40 kg/m who have not responded adequately to pharmacotherapy, though insurance criteria may vary
Clinical trials of tirzepatide show that gastrointestinal side effectsincluding nausea, vomiting, and burpingoccur in 2550% of patients, with severity typically highest in the first 48 weeks
In addition, no covariate (in particular dosage) was incorporated into the E max model, showing there was no significant dose-dependence from l-carnitine efficacy on BMI in T2DM patients
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