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No clinical trial has evaluated BPC-157 in users with active malignancy

Also, individuals who have undergone certain surgical procedures, including intestinal resection, bypass, or bariatric surgery, which may reduce Vitamin B12 absorption, are also eligible

Theoretically, the two compounds target completely different receptor systems (amylin receptors for cagrilintide, GLP-1/GIP/glucagon for retatrutide), which suggests they could work synergistically without receptor overlap

The key difference is that retatrutide provides triple agonism (GLP-1 + GIP + glucagon) while semaglutide provides only GLP-1 agonism