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The two medications belong to entirely different drug classes, work through completely separate mechanisms, and produce different clinical outcomes
This endothelial dysfunction decreases the potent vasodilator nitric oxide (NO) in endothelial and vascular muscle smooth cells, increases the levels of vasoconstrictors such as endothelin-1 [13], and creates a hypercoagulable state by activating platelet aggregation and inhibiting fibrinolysis [14]
Correspondingly, total allowed costs rose from $53.4 million in 2019 to $116.7 million in 2023
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