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published in 2010 provides tremendous insight into the early steps in the misfolding of IAPP that eventually leads to -cell destruction

According to the study conducted by Nagashima et al., treatment of 17-week-old mice with GIP via subcutaneous injection showed a significant decrease in the size of aortic atherosclerotic lesions and macrophage infiltration

This triple mechanism has produced the most dramatic weight loss numbers ever recorded in clinical trials for an anti-obesity medication