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Effects of statins on microglia
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310 Key mechanisms supporting DTP survival include chromatin reconfiguration mediated by histone-modifying enzymes, activation of stress-response and bypass signaling pathways such as IGF-1R, AXL and YAP/TAZ, and a shift toward oxidative or alternative nutrient metabolism, often coupled with enhanced mitochondrial ETC dependency, selective mitophagy and resistance to lipid peroxidation, which together mitigate therapy-induced apoptosis
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