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It has been found that research has mostly been conducted on the animals and little evidence has been found on the canine itself, thus it should never be used in place of professional veterinary care

We are conscious of the limitations of the animal models [123], however in a clinical trial undertaken by this group to asses IGF-1 in liver function under cirrhosis with these same dosage (20 g/kg/day) no side effects were reported and liver function greatly increased [108]