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In a January 2024 update, the FDA stated that its preliminary evaluation has not found evidence that GLP-1 RAs cause suicidal thoughts or actions, based on available clinical trial data and adverse event reports (FDA Drug Safety Communication, 2024)
While no direct head-to-head trials have compared oral semaglutide with injectable semaglutide at diabetes doses, indirect comparisons across clinical trials suggest that injectable formulations generally provide greater efficacy for both glycemic control and weight reduction
Patients with T2D typically lose less weight on anti-obesity medications than those without diabetes
Muscle loss slows your metabolism, weakens your bones, and can make weight regain more likely if you ever discontinue the medication
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