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The Initial Boost: What to Expect After Your First Shot If youve been diagnosed with a significant B12 deficiency, your GP will likely prescribe an initial course of injections, often called a loading dose phase

Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk

If youre taking these or other medications, consult your healthcare provider to adjust the timing or dosage of B12 supplementation to avoid potential interactions

Heinemann L et al