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Transdermal Creams: Some formulations allow topical application, which may enhance localized absorption
C.GurdJ
In controlled studies, participants experienced up to 35% improvement in facial wrinkles over 12 weeks of consistent use
10,15,91 Of current interest is estetrol, which is a natural estrogen that spares the endometrium, while being an estrogen receptor agonist in the tissues, including the skin, that deteriorate following the loss of estradiol in the post-menopausal period
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