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For example, patients with genetic predispositions toward lower NAD+ availability may experience better weight loss sustainability and reduced side effect burden when NAD+ restoration is integrated into their GLP-1 regimen

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Recent data have indicated that such an effect may depend on the influence on metabolic processes because in chronic unpredictable mild stress (CUMS) in mice, the decreased GLP-1 level in the hippocampus was increased with metformin treatment [46]