Common adverse effects include nausea, vomiting, diarrhea, constipation, and abdominal pain, which typically diminish over time as the body adjusts to treatment
They mimic the action of endogenous glucagon-like peptide 1, a hormone involved in glucose regulation and appetite control
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A real-world comparison study found that oral semaglutide users lost an average of 3.64 kg in 6 months versus 5.26 kg for injectable users, though the difference was not statistically significant