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Extremely cold temperatures or freezing can damage their protein structure, reduce their medicinal effect, and potentially make them unsafe to use even after thawing If you believe your weight-loss injection has been frozen, dispose of it immediately. The MHRA told The Guardian they were unable to comment on an ongoing investigation
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J Musculoskelet Neuronal Interact 21:142148 Cheng Y, Liu P, Xiang Q, Liang J, Chen H, Zhang H, Yang L (2022) Glucagon-like peptide-1 attenuates diabetes-associated osteoporosis in ZDF rat, possibly through the RAGE pathway
Importantly, hemodynamic effects - modest reductions in heart rate (+2-4 bpm) and blood pressure decreases - are generally well tolerated and beneficial in this population
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