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Melanotan-2 oral taste is among the most bitter of any peptide commonly administered sublingually, primarily due to its cyclic structure and charged amino acid residues (histidine and arginine)
Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
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DG-75 and BL-2 cell lines were incubated with viral particles in culture medium with 8 g/ml protamine sulfate during 16 h
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