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Sedation and tiredness were commonly reported with drugs targeting the opioid receptors (like naltrexone) and combination therapies that target both the opioid and monoamine systems (such as Contrave)
References Tan B, Pan XH, Chew HSJ, Goh RSJ, Lin C, Anand VV, et al
The good news is that early evidence on oral semaglutide suggests a potential advantage here: One study showed that oral semaglutide improved blood sugar and reduced body fat while not significantly affecting muscle mass in those with type 2 diabetes
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