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Exenatide-PD3, reported in The Lancet in early 2025, was the largest and longest trial of a GLP-1R agonist in Parkinsons disease: 194 patients, once-weekly exenatide, 96 weeks
doi: 10.1002/ctm2.70337 48 ShiXZouWLiXLiuSHuTLiQet al
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The 500 Dalton rule means even the smaller patch ingredients face significant permeation barriers, and the doses used (8.75 mg berberine) are a tiny fraction of studied oral doses (900-1,500 mg)
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