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HRD1 interacts with the Neh4 and Neh5 domains of NRF2 and causes NRF2 ubiquitination and subsequent degradation through a KEAP1-independent mechanism, just like GSK-3 [227, 228]
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Rao M, Zumbro E, Dixon M, Kaiser K, Sebastian L, McAdams D, LeMieux M, Broughton KS
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