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In one study, older individuals with a history of chronic constipation were more than three times as likely to develop Parkinsons disease during an average 5.5 years of follow-up, and those with the most severe constipation had the greatest risk (Lin 2014)

2.2.2 ERK1/2-HDAC6 signaling pathway The GLP-1R-ERK1/2-HDAC6 signaling pathway complements the mitophagy pathway by modulating oxidative stress and autophagy

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