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Antioxidants 10:1220
This would further reduce the hepatic GSH content by means of enhancing the efflux of GSH from the intercellular space, and then further aggravate the redox imbalance
The oxidative stress caused by a decrease in GSH levels can then impact microglia function and potentially lead to a more pro-inflammatory M1 phenotype that has reduced -amyloid clearance capabilities (Vilhardt et al., 2017)
Fortunately, glutathione mitigates the damage caused by free radicals through its antioxidant properties
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