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The evidence from literature suggests that chronic exposure to external stressors may exacerbate oocyte senescence by stimulating production of reactive oxygen species (ROS)

We showed that the GCLC mRNA expression level was downregulated by ACTL6A KD and was upregulated when ACTL6A was overexpressed, but the GCLM expression was not changed (Supplementary Fig 5a, b)

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