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doi: 10.1007/s00592-018-1134-y 46 BenhalimaKMathiesenERPaldaniusPMMathieuC
The delivery methods also differ considerably - while injections provide controlled, consistent release of medication through subcutaneous administration, patches rely on unproven transdermal delivery that cannot effectively transport the hormone through the skin barrier
There is a gradient of reactive morphotypes, with the most reactive cells (border-forming astrocytes and amoeboid microglia) concentrating at the lesion perimeter, or even entering (reactive microglia) the lesion core
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