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Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects
How GLP-1 Medications Work (And Why Your Stomach Notices) GLP-1 stands for glucagon-like peptide-1, a hormone your body naturally makes in your gut after you eat
Note that with normal to high glucose, GABA inhibits alpha-cell glucagon release (164)
Endocrinologists viewed their ideal patient as an individual with established cardiovascular disease or high cardiovascular risk, including those with diabetic kidney disease, who are already being treated with more than one oral medication (including either SGLT2is or GLP1-RAs) and an HbA1c level exceeding the established target
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