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Cannabinoid structures were prepared by enumeration of chiral centers, major tautomeric structure selection, removal of structural faults, ionization at the pH of 7.4 and minimization (using OPLS3e force-field) to generate the final 3D conformations used as docking input structures

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doi: 10.1093/jjco/hyab048 42 HanXChenLHuZChenLSunPWangYet al

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