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A 2023 network meta-analysis published in JAMA Network Open (N=22 trials, 17,604 participants) estimated that tirzepatide 15 mg produced roughly 5 to 6 additional percentage points of weight loss compared with semaglutide 2.4 mg, after adjusting for trial-level covariates [8]
Some lower-quality supplements use the oxidized form, which your body then has to spend energy converting before it can use it
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