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Creatine supplementation may modestly increase measured serum creatinine levels, which can confound creatinine-based estimated glomerular filtration rate (eGFR) calculations

Its high molecular weight and high fixation to plasma proteins make it very unlikely to pass into mothers milk in a clinically significant quantity

Quality of life, as measured by DLQI, improved by at least 4 points in 33.3% of patients with a mean DLQI reduction of 13 to 9 out of 30 (adjusted P = .001)

In a head-to-head trial published in the New England Journal of Medicine in May 2025, Mounjaro users lost 20.2 percent of body weight compared to 13.7 percent for Wegovy users