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A clinically significant interaction exists between tirzepatide and oral contraceptives, requiring backup contraception for 4 weeks after initiation and each dose increase, and patients taking levothyroxine or other time-sensitive medications warrant closer monitoring
The new algorithm in the validation model a) had a c-statistics of 0.651 with accurate classification of definite AH in 80% (Brier score 0.204), b) performed better than NIAAA criteria at a cut-off score of 0.291, and c) showed good calibration between expected and observed probability, correlation coefficient 0.839 (Figure)
Being able to visualize progress in this way helps to monitor progress and reinforce positive behavior changes
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